The Bluejays improved to 3-9 in league play and 14-18 overall, while the Wildcats fell to 4-5 during conference action and 20-19 overall.
Creighton and Villanova split a doubleheader on Saturday.
Bluejay senior Laura Roecker allowed two unearned runs in the bottom of the first inning before Creighton scored eight times unanswered.
Victoria Alvarez tied the game at 2-2 during the top of the second frame with a two-run homer to left field for her first career long ball. Kailey Wilson drew a one-out walk before Alvarez tied the game with one swing of the bat.
The Bluejays took the lead with a two-RBI single by Mikaela Pechar in the third. With the bases loaded, Pechar launched a 1-0 delivery into the right-field corner to drive in Kiara Mills and Sam Alm. Jayci Foster extended Creighton’s edge to five runs with a three-run homer to center. The senior lifted the first pitch of her at-bat over the center-field wall and gave the Bluejays a 7-2 lead.
Alvarez scored Creighton’s eighth run of the game during the sixth. The sophomore doubled down the left-field line before advancing to third on Kaitlynn Hunt’s sacrifice bunt and scoring on Ashley Cantu’s RBI ground out to first.
Alvarez, Cantu and Pechar each finished with two hits and at least one RBI to pace the Creighton offense, while Foster tallied three RBIs with her second home run of the season.
Roecker pitched her second complete-game of the weekend and scattered six hits while not allowing an earned run. She struck out three, walked two and recorded her team-leading seventh victory of the season. The senior escaped a bases loaded jam in the sixth with her final strikeout of the game. Villanova left a total of 10 runners on base on Sunday.
Creighton steps out of conference play for a contest against crosstown foe Nebraska-Omaha on Tuesday afternoon. First pitch between the Bluejays and Mavericks is scheduled for 4 p.m. at Westside Field at Westbrook.